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Reactive oligonucleotide derivatives and sequence-specific modification of nucleic acids

✍ Scribed by KNORRE, D; VLASSOV, V; ZARYTOVA, V


Book ID
123072849
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
224 KB
Volume
67
Category
Article
ISSN
0300-9084

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Sequence-specific chemical modification
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Chemical modification of the chromatin DNA with alkylating derivatives of oligothymidylate (pT)16 and oligoadenylate (pA)16 bearing 4-(N-2-chloroethyl-N-methylamino)benzylphosphamide group at the 5'-phosphate has been investigated. It was found that the derivatives do react with DNA in chromatin. Th