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Reactive Nitrogen Species in Acetaminophen-Induced Mitochondrial Damage and Toxicity in Mouse Hepatocytes

✍ Scribed by Burke, Angela S.; MacMillan-Crow, Lee Ann; Hinson, Jack A.

Book ID
127222545
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
454 KB
Volume
23
Category
Article
ISSN
0893-228X

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Acetaminophen overdose causes massive hepatic failure via mechanisms involving glutathione depletion, oxidative stress, and mitochondrial dysfunction. The ultimate target of acetaminophen causing cell death remains uncertain, and the role of apoptosis in acetaminophen-induced cell killing is still c