Reactive intermediates in the H-phosphonate synthesis of oligonucleotides
β Scribed by Powles, Nicholas; Atherton, John; Page, Michael I.
- Book ID
- 111882004
- Publisher
- Royal Society of Chemistry
- Year
- 2012
- Tongue
- English
- Weight
- 718 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1477-0520
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Nucleoside H-Phosphonates are used directly in the synthesis of H-phosphonate linked deoxyoligonucleotides. A rapid and simplified procedure for the synthesis of deoxyoligonucleotides is described. Ribonucleoside H-phosphonate I. was introduced by Todd to prepare diribonucleotide 1 phosphate 4 (Sche
Polymer bound deoxynucleoside H-phosphonate diesters are used as precursors to phosphoramidate, thiophosphate and phosphate triester analogues of DNA.
## Abstract An efficient and stereoselectiveβsynthesis of 3βaminoβ1βalkenylphosphonates by a direct procedure involving alkylidene diphosphorylation of nucleophiles followed by a HornerββEmmons olefination of aminoaldehydes is reported. The versatility of the method is illustrated by the preparatio