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Reactive intermediates in the H-phosphonate synthesis of oligonucleotides

✍ Scribed by Powles, Nicholas; Atherton, John; Page, Michael I.


Book ID
111882004
Publisher
Royal Society of Chemistry
Year
2012
Tongue
English
Weight
718 KB
Volume
10
Category
Article
ISSN
1477-0520

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## Abstract An efficient and stereoselective‐synthesis of 3‐amino‐1‐alkenylphosphonates by a direct procedure involving alkylidene diphosphorylation of nucleophiles followed by a Horner‐‐Emmons olefination of aminoaldehydes is reported. The versatility of the method is illustrated by the preparatio