Deoxynucleoside H-Phosphonate diester intermediates in the synthesis of internucleotide phosphate analogues
β Scribed by Brian C. Froehler
- Book ID
- 104219348
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 380 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Polymer bound deoxynucleoside H-phosphonate diesters are used as precursors to phosphoramidate, thiophosphate and phosphate triester analogues of DNA.
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Nucleoside H-Phosphonates are used directly in the synthesis of H-phosphonate linked deoxyoligonucleotides. A rapid and simplified procedure for the synthesis of deoxyoligonucleotides is described. Ribonucleoside H-phosphonate I. was introduced by Todd to prepare diribonucleotide 1 phosphate 4 (Sche