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Deoxynucleoside H-Phosphonate diester intermediates in the synthesis of internucleotide phosphate analogues

✍ Scribed by Brian C. Froehler


Book ID
104219348
Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
380 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis


Polymer bound deoxynucleoside H-phosphonate diesters are used as precursors to phosphoramidate, thiophosphate and phosphate triester analogues of DNA.


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Nucleoside H-Phosphonates are used directly in the synthesis of H-phosphonate linked deoxyoligonucleotides. A rapid and simplified procedure for the synthesis of deoxyoligonucleotides is described. Ribonucleoside H-phosphonate I. was introduced by Todd to prepare diribonucleotide 1 phosphate 4 (Sche