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Reactions of 1-ethyl-3-azabicyclo[1.1.0]butane with electrophiles. A facile entry into new, N-substituted 3-ethylideneazetidines and 2-azetines

✍ Scribed by Marchand, Alan P.; Rajagopal, D.; Bott, Simon G.; Archibald, Thomas G.


Book ID
120642350
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
739 KB
Volume
59
Category
Article
ISSN
0022-3263

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Reactions of 4-Oxoalkanoic Acids, 4. Syn
✍ Wedler, Christine ;Schick, Hans ;Scharfenberg-Pfeiffer, Doris ;Reck, GΓΌnter πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 432 KB

## Abstract Ethyl 4‐oxoalkanoates 1 react at ambient temperature in dry methanol in the presence of molecular sieve 3 Γ… in almost quantitative yield with 3‐aminopropanol and 2‐aminoethanol to form the bicyclic lactams __rac__‐2 and __rac__‐3, respectively. Surprisingly, the (Β±)‐5‐alkyl‐4‐oxa‐1‐azab