Reaction of 2-acetyl-6-chloro-cis-bicyclo-[3.3.0]octane with base
β Scribed by John N. Labows Jr.
- Publisher
- Elsevier Science
- Year
- 1970
- Tongue
- French
- Weight
- 141 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The Michael addition of dimethyl malonate (12) to __tert__βbutyl acrylate (11), carried out without solvent, affords the triester 13a in 88% yield on a kg scale. Selective partial hydrolysis of 13a produces the monoacid 13b almost quantitatively. The Kolbe electrolysis of 13b furnishes
Extraction with ethyl acetate or ether and distillation of the crude furnishes pure (2). As shown in the reaction scheme, the overall reaction proceeds via several unisolated intermediates and it has not yet been established whether the cyclization occurs with (la) or ( 1 b). Remarkably, in the pres