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Synthesis of substituted cis-bicyclo[3.3.0]octane-1-carbonyl derivatives by stereospecific rearrangement of 1-chloro- 9-hydroxybicyclo [3.3.1] nonanes

โœ Scribed by Augusto Gambacorta; Stefano Turchetta; Paolo Bovicelli; Maurizio Botta


Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
520 KB
Volume
47
Category
Article
ISSN
0040-4020

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โœ Eugene A. Mash; Kalpana S. Nimkar; James A. Baron ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 776 KB

Conformations of the title compound were studied using a Monte Carlo search technique. Two principal conformational motifs were observed for the bicyclic carbocycle in which both faces of the carbonyl appear susceptible to nucleophilic attack. The title compound was synthesized in eight steps from