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Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase

โœ Scribed by Kamura, T.


Book ID
115459218
Publisher
American Association for the Advancement of Science
Year
1999
Tongue
English
Weight
431 KB
Volume
284
Category
Article
ISSN
0036-8075

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Rbx1, a Component of the VHL Tumor Suppr
โœ Kamura, T. ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› American Association for the Advancement of Scienc ๐ŸŒ English โš– 431 KB

The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in most human kidney cancers. The VHL protein is part of a complex that includes Elongin B, Elongin C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination. Here it is shown that the endogenous VHL complex i