Rbx1, a Component of the VHL Tumor Suppr
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Kamura, T.
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Article
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1999
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American Association for the Advancement of Scienc
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English
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The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in most human kidney cancers. The VHL protein is part of a complex that includes Elongin B, Elongin C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination. Here it is shown that the endogenous VHL complex i