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The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

✍ Scribed by Richard Baer; Thomas Ludwig

Book ID
117654841
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
129 KB
Volume
12
Category
Article
ISSN
0959-437X

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The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in most human kidney cancers. The VHL protein is part of a complex that includes Elongin B, Elongin C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination. Here it is shown that the endogenous VHL complex i