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Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex

โœ Scribed by Yuzuru Megumi; Yasuhiro Miyauchi; Hitomi Sakurai; Hiroyuki Nobeyama; Kevin Lorick; Eijiro Nakamura; Tomoki Chiba; Keiji Tanaka; Allan M. Weissman; Takayoshi Kirisako; Osamu Ogawa; Kazuhiro Iwai

Book ID
108731781
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
367 KB
Volume
10
Category
Article
ISSN
1356-9597

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Rbx1, a Component of the VHL Tumor Suppr
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
โœ Kamura, T. ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› American Association for the Advancement of Scienc ๐ŸŒ English โš– 431 KB

The von Hippel-Lindau (VHL) tumor suppressor gene is mutated in most human kidney cancers. The VHL protein is part of a complex that includes Elongin B, Elongin C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination. Here it is shown that the endogenous VHL complex i