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RB regulates transcription of the p21/WAF1/CIP1 gene

✍ Scribed by Decesse, Julien T; Medjkane, Souhila; Datto, Michael B; Crémisi, Chantal E

Book ID
110064465
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
227 KB
Volume
20
Category
Article
ISSN
0950-9232

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WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet