CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene
β Scribed by Bai, Yun-Qing; Miyake, Satoshi; Iwai, Takehisa; Yuasa, Yasuhito
- Book ID
- 110067730
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 287 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Transforming growth factorβΞ² (TGFβΞ²) inhibits epithelial cell growth, in part via transcriptional induction of the cell cycle inhibitor p21^WAF1/Cip1^ (p21). We show that bone morphogenetic protein (BMP)β7 induces higher p21 expression than TGFβΞ²1 in various epithelial cells. Despite th