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Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

✍ Scribed by Christ, Frauke; Voet, Arnout; Marchand, Arnaud; Nicolet, Stefan; Desimmie, Belete A; Marchand, Damien; Bardiot, Dorothée; Van der Veken, Nam Joo; Van Remoortel, Barbara; Strelkov, Sergei V


Book ID
109913376
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
858 KB
Volume
6
Category
Article
ISSN
1552-4450

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Computational studies of the interaction
✍ Cristina Tintori; Nevena Veljkovic; Veljko Veljkovic; Maurizio Botta 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 542 KB

## Abstract A crystal structure of the integrase binding domain (IBD) of the lens epithelium‐derived growth factor (LEDGF/p75) in complex with the dimer of the HIV‐1 integrase (IN) catalytic core domain (CCD) provides useful information that might help in the understanding of essential protein‐prot