𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Inhibitors of the Interactions between HIV-1 IN and the Cofactor LEDGF/p75

✍ Scribed by Dr. Laura De Luca; Dr. Stefania Ferro; Dr. Francesca Morreale; Dr. Sara De Grazia; Prof. Alba Chimirri

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
471 KB
Volume
6
Category
Article
ISSN
1860-7179

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Crystal Structures of Novel Allosteric P
Crystal Structures of Novel Allosteric Peptide Inhibitors of HIV Integrase Identify New Interactions at the LEDGF Binding Site
✍ Dr. David I. Rhodes; Dr. Thomas S. Peat; Dr. Nick Vandegraaff; Dharshini Jeevara 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 959 KB

## Abstract An optimised method of solution cyclisation gave us access to a series of peptides including SLKIDNLD (**2**). We investigated the crystallographic complexes of the HIV integrase (HIV‐IN) catalytic core domain with 13 of the peptides and identified multiple interactions at the binding s

Kinetic Analysis of the Interaction betw
Kinetic Analysis of the Interaction between HIV-1 Protease and Inhibitors Using Optical Biosensor Technology
✍ Per-Olof Markgren; Markku Hämäläinen; U.Helena Danielson 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 97 KB

The interaction between HIV-1 protease and reversible inhibitors was studied by surface plasmon resonance biosensor technology. The steady-state binding level and the time course of association and dissociation could be observed by measuring the binding of inhibitors injected in a continuous flow of

Using peptides to study the interaction
Using peptides to study the interaction between the p53 tetramerization domain and HIV-1 tat
✍ Ronen Gabizon; Michal Mor; Masha M. Rosenberg; Lena Britan; Zvi Hayouka; Moshe K 📂 Article 📅 2008 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 367 KB

## Abstract Peptides are valuable tools for studying protein–protein interactions, especially in cases of isolated protein domains and natively unfolded proteins. Here, we used peptides to quantitatively characterize the interaction between the natively unfolded HIV‐1 Tat protein and the tetrameriz

Conformational analysis of HIV-1 proteas
Conformational analysis of HIV-1 protease inhibitors: 2. Thioproline P1? Residue in the potent inhibitor KNI-272
✍ Murcko, Mark A.; Rao, B. Govinda; Gomperts, Roberto 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 287 KB 👁 2 views

does not contain a basic amine as do Saquinovir and JG-365, for example it should be easier to desolvate, which also assists in binding. The relationship between KNI-272, JG-365, Saquinovir, and P X proline-containing substrate also is 1