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Conformational analysis of HIV-1 protease inhibitors: 2. Thioproline P1? Residue in the potent inhibitor KNI-272

✍ Scribed by Murcko, Mark A.; Rao, B. Govinda; Gomperts, Roberto

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 287 KB
Volume: 18
Category: Article
ISSN: 0192-8651
DOI: 10.1002/(sici)1096-987x(19970715)18:9<1151::aid-jcc4>3.0.co;2-q

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✦ Synopsis

does not contain a basic amine as do Saquinovir and JG-365, for example it should be easier to desolvate, which also assists in binding. The relationship between KNI-272, JG-365, Saquinovir, and P X proline-containing substrate also is 1

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