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Rational design of new bifunctional inhibitors of type II dehydroquinase

✍ Scribed by Toscano, Miguel D.; Stewart, Kirsty A.; Coggins, John R.; Lapthorn, Adrian J.; Abell, Chris


Book ID
115538507
Publisher
Royal Society of Chemistry
Year
2005
Tongue
English
Weight
182 KB
Volume
3
Category
Article
ISSN
1477-0520

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## Abstract The inβ€…silico design, synthesis, and biological evaluation of ten potent type II dehydroquinase inhibitors are described. These compounds contain an anhydroquinate core, incorporated as a mimic of the enolate reaction intermediate. This substructure is attached by a variety of linking u