Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase
✍ Scribed by Verónica F. V. Prazeres; Cristina Sánchez-Sixto; Luis Castedo; Heather Lamb; Alastair R. Hawkins; Alan Riboldi-Tunnicliffe; John R. Coggins; Adrian J. Lapthorn; Concepción González-Bello
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 646 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1860-7179
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## Abstract The in silico design, synthesis, and biological evaluation of ten potent type II dehydroquinase inhibitors are described. These compounds contain an anhydroquinate core, incorporated as a mimic of the enolate reaction intermediate. This substructure is attached by a variety of linking u
## Abstract Several 3‐heteroaryl analogs of the known dehydroquinase inhibitor (1R,4R,5R)‐1,4,5‐trihydroxy‐2‐cyclohexene‐1‐carboxylic acid (**4**) were synthesized and tested as inhibitors of Helicobacter pylori type II dehydroquinase, the third enzyme of the shikimic acid pathway. All of these com