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Synthesis and Evaluation of Potent Ene–yne Inhibitors of Type II Dehydroquinases as Tuberculosis Drug Leads

✍ Scribed by Anh Thu Tran; Dr. Katie M. Cergol; Dr. Nicholas P. West; Elizabeth J. Randall; Prof. Warwick J. Britton; Syed Ali Imran Bokhari; Musadiq Ibrahim; Dr. Adrian J. Lapthorn; Dr. Richard J. Payne


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
306 KB
Volume
6
Category
Article
ISSN
1860-7179

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## Abstract The in silico design, synthesis, and biological evaluation of ten potent type II dehydroquinase inhibitors are described. These compounds contain an anhydroquinate core, incorporated as a mimic of the enolate reaction intermediate. This substructure is attached by a variety of linking u

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