## Abstract The in silico design, synthesis, and biological evaluation of ten potent type II dehydroquinase inhibitors are described. These compounds contain an anhydroquinate core, incorporated as a mimic of the enolate reaction intermediate. This substructure is attached by a variety of linking u
✦ LIBER ✦
Synthesis and Evaluation of Potent Ene–yne Inhibitors of Type II Dehydroquinases as Tuberculosis Drug Leads
✍ Scribed by Anh Thu Tran; Dr. Katie M. Cergol; Dr. Nicholas P. West; Elizabeth J. Randall; Prof. Warwick J. Britton; Syed Ali Imran Bokhari; Musadiq Ibrahim; Dr. Adrian J. Lapthorn; Dr. Richard J. Payne
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 306 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1860-7179
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## Abstract Several 3‐heteroaryl analogs of the known dehydroquinase inhibitor (1R,4R,5R)‐1,4,5‐trihydroxy‐2‐cyclohexene‐1‐carboxylic acid (**4**) were synthesized and tested as inhibitors of Helicobacter pylori type II dehydroquinase, the third enzyme of the shikimic acid pathway. All of these com