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Rational Design, Discovery, and Synthesis of a Novel Series of Potent Growth Hormone Secretagogues⊥

✍ Scribed by Huang, Ping; Loew, Gilda H.; Funamizu, Hidenori; Mimura, Mitsuo; Ishiyama, Nobuo; Hayashida, Mitsuo; Okuno, Tadashi; Shimada, Osafumi; Okuyama, Akihiko; Ikegami, Satoru


Book ID
115528132
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
391 KB
Volume
44
Category
Article
ISSN
0022-2623

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The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating