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Design, Synthesis, and Antiangiogenic Effects of a Series of Potent Novel Fumagillin Analogues.

✍ Scribed by Hong Woo Lee; Chin Sung Cho; Sung Kwon Kang; Yong Sang Yoo; Jae Soo Shin; Soon Kil Ahn

Publisher
John Wiley and Sons
Year
2007
Weight
15 KB
Volume
38
Category
Article
ISSN
0931-7597

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## Abstract Fibroblast growth factor‐1 (FGF1), a prototypic member of the FGF family, is a potent angiogenic factor. Although FGF‐stimulated angiogenesis has been extensively studied, the molecular mechanisms regulating FGF1‐induced angiogenesis are poorly understood in vivo. Fumagillin, an antiang