The effect of structural variations on the rates of elastase-catalyzed hydrolysis of model carbonate and carbamate esters was studied using HPLC. It is shown that branching in the immediate vicinity of the carbonate or carbamate functionally results in decreased hydrolysis rates. Whereas aryl carbon
Rates of hydrolysis of carbamate and carbonate esters in alkaline solution
โ Scribed by Lewis W. Dittert; Takeru Higuchi
- Publisher
- John Wiley and Sons
- Year
- 1963
- Tongue
- English
- Weight
- 532 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0022-3549
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## Abstract Reaction rate constants for the hydrolysis of organic esters and amides were determined at temperatures of 100โ240ยฐC in aqueous solutions buffered at pH values between 5.5 and 7.3. Experiments are modeled assuming alkaline hydrolysis with a thermodynamic solution model included to accou
A two-step s y n t h e s i s of t h r e e carbonate and f o u r carbamate esters l a b e l e d a t t h e carbonyl with c a r n-14 i s described. The method u t i l i z e s t h e r e a d i l y a v a i l a b l e [' %I -phosgene which i s f i r s t converted t o an i s o l a b l e [14C] -labeled a l k