Rat liver sinusoidal endothelial cells (LSECs) express functional low density lipoprotein receptor-related protein-1 (LRP-1)
✍ Scribed by Cristina Ionica Øie; Rupa Shree Appa; Ida Hilden; Helle Heibroch Petersen; Albrecht Gruhler; Bård Smedsrød; John-Bjarne Hansen
- Book ID
- 116652459
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 863 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0168-8278
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Low density lipoprotein receptor-related protein (LRP) participates in the uptake and degradation of several ligands implicated in neuronal pathophysiology including apolipoprotein E (apoE), activated ␣ 2 -macroglobulin (␣ 2 M\*) and -amyloid precursor protein (APP). The receptor is expressed in a
## Abstract Low‐density lipoprotein receptor‐related protein 1 (LRP1) is an endocytic receptor, which binds and internalizes diverse ligands such as activated α~2~‐macroglobulin (α~2~M\*). LRP1 promotes intracellular signaling, which downstream mediates cellular proliferation and migration of diffe