Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma

Activated α2 macroglobulin induces matri

Activated α2 macroglobulin induces matrix metalloproteinase 9 expression by low-density lipoprotein receptor-related protein 1 through MAPK-ERK1/2 and NF-κB activation in macrophage-derived cell lines

✍ Leandro C. Cáceres; Gustavo R. Bonacci; María C. Sánchez; Gustavo A. Chiabrando 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 726 KB

## Abstract Macrophages under certain stimuli induce matrix metalloproteinase 9 (MMP‐9) expression and protein secretion through the activation of MAPK‐ERK and NF‐κB signaling pathways. Previously, we demonstrated that activated α~2~‐macroglulin (α~2~M\*) through the interaction with its receptor l