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Rat and hamster hepatocyte-mediated induction of SCEs and mutation in V79 cells and mutation of Salmonella by aminofluorene and dimethylnitrosamine

โœ Scribed by Robert Langenbach; Sharon Leavitt; Cathy Hix; Yousuf Sharief; James W. Allen


Book ID
113193031
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
726 KB
Volume
161
Category
Article
ISSN
0027-5107

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Mutation induction in chinese hamster V7
โœ Eliezer Huberman; Helmut Bartsch; Leo Sachs ๐Ÿ“‚ Article ๐Ÿ“… 1975 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 421 KB

## Abstract Chloroethylene oxide and 2โ€chloroacetaldehyde, two possibly carcinogenic metabolites of vinyl chloride in mammals, caused a doseโ€dependent induction of 8โ€azaguanineโ€and ouabainโ€resistant mutants in Chinese hamster V79 cells in vitro. Up to oneโ€hundredfold higher concentrations of 2โ€chlo