✦ LIBER ✦
Mutation induction in chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde
✍ Scribed by Eliezer Huberman; Helmut Bartsch; Leo Sachs
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- French
- Weight
- 421 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Chloroethylene oxide and 2‐chloroacetaldehyde, two possibly carcinogenic metabolites of vinyl chloride in mammals, caused a dose‐dependent induction of 8‐azaguanine‐and ouabain‐resistant mutants in Chinese hamster V79 cells in vitro. Up to one‐hundredfold higher concentrations of 2‐chloroethanol or monochloroacetic acid, a urinary vinyl chloride metabolite in rats and man, were inactive.