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Substitutional effects of styrene oxides on survival and mutation induction in cultured Chinese hamster cells (V-79)

โœ Scribed by Katsura Sugiura; Akira Maeda; Miki Goto


Book ID
119020704
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
175 KB
Volume
8
Category
Article
ISSN
0045-6535

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Mutation induction in chinese hamster V7
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## Abstract Chloroethylene oxide and 2โ€chloroacetaldehyde, two possibly carcinogenic metabolites of vinyl chloride in mammals, caused a doseโ€dependent induction of 8โ€azaguanineโ€and ouabainโ€resistant mutants in Chinese hamster V79 cells in vitro. Up to oneโ€hundredfold higher concentrations of 2โ€chlo