Ras and p53 expression in human thyroid carcinoma
β Scribed by Xiao-xi Li; Hui-qian Wu; Guo-hua Zhao; Shen-ming Wang; Guo-rui Chen
- Publisher
- Chinese Anti-Cancer Association
- Year
- 2000
- Tongue
- English
- Weight
- 401 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1000-9604
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Abnormalities of the p53 gene have been identified in many malignancies, with reports of aberration in over half of colorectal, lung, breast and hepatocellular carcinoma cases. The normal gene acts as a recessive oncogene, while mutations change the apparent function to that of a domina
Medullary thyroid carcinoma (MTC) is an uncommon tumour of calcitonin-secreting C-cells of the thyroid gland. This cancer represents an important potential model for the study of mechanisms of human epithelial cell transformation. Although recent studies have identified the gene involved in familial
Mutation of the tumor-suppressor gene p53 is involved in carcinogenetics. We investigated the role of p53 in the induction of anti-tumor immune responses by establishing a thyroid carcinoma cell line (1F3) prepared by transfection of wild-type human p53 gene into a p53-deficient cell line (FRO). Our