Clinical Significance of P53 Protein Expression in Papillary Thyroid Carcinoma
โ Scribed by Naomi Morita; Yoshifumi Ikeda; Hiroshi Takami
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 193 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0364-2313
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## BACKGROUND. Alterations in the expression of p53 tumor suppressor protein is a frequent event in human cancer but the practical implications of this phenomenon are yet to be fully exploited. The objective of this study was to determine the value of p53 accumulation as a marker of tumor progress
## Abstract In order to better understand basic mechanisms of tumor development and identify potential new biomarkers, we have performed difference gel electrophoresis (DIGE) and peptide mass fingerprinting on pooled protein extracts from patients with papillary thyroid carcinoma (PTC) compared wit