𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Rare Ha-ras1 alleles and predisposition to testicular cancer

✍ Scribed by David Ryberg; Aage Haugen; Ketil Heimdal; Anne-Lise Børresen; Sophie Dorothea Fosså

Book ID
102277799
Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
292 KB
Volume
53
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

We have examined the restriction-fragment-length polymorphism (RFLP) of the VNTR region flanking the Ha-ras I gene in genomic DNA from 348 testicular cancer patients and 343 healthy controls. When DNA samples were digested with MspllHpall, Southern blot analysis revealed 24 and 15 different alleles in the cancer and the control group respectively. The frequency of rare alleles among cases was significantly higher than in controls. Patients with bilateral cancer and patients with unilateral cancer below 20 years had significantly higher incidence of rare alleles than patients with unilateral cancer older than 20 years.

📜 SIMILAR VOLUMES

Lack of correlation between rare Ha-ras
Lack of correlation between rare Ha-ras alleles and urothelial cancer in Japan
✍ Jiro Ishikawa; Sakan Maeda; Rei Takahashi; Sadao Kamidono; Taketoshi Sugiyama 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 604 KB

Restriction fragment length polymorphism (RFLP) of Ha- In the present studies, the role of Ha-ras RFLP in cancer ras gene was surveyed by Southern blot analysis in leukocyte susceptibility and expression of Ha-rus gene was investigated DNA from 55 normal individuals and 58 urothelial cancer in urot