Two studies on breast cancer patients are described. Our aim was to examine whether the combined frequency of rare c-Ha-ras-l alleles in cancer patients was raised. Firstly, the c-Ha-ras-l locus in 56 breast cancer patients and 48 controls was examined for restriction fragment length polymorphism (R
Distribution of Ha-RAS-1 proto-oncogene alleles in breast cancer patients and in a control population
✍ Scribed by Giuseppe Saglio; Clara Camaschella; Maurizia Giai; Anna Serra; Angelo Guerrasio; Bruno Peirone; Paolo Gasparini; Umberto Mazza; Ruggero Ceppellini; Nicoletta Biglia; Paolo Cortese; Piero Sismondi
- Publisher
- Springer US
- Year
- 1988
- Tongue
- English
- Weight
- 945 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Restriction fragment length polymorphism analyses of the Ha-ras-1 proto-oncogene were undertaken in white and black populations residing in the Baltimore-Washington metropolitan area to address whether specific rare alleles of the Ha-ras-1 proto-oncogene locus vary in their distribution among differ
Analysis of 426 alleles of the human Ha-rasl locus in DNA samples of cancer patients and controls reveals no obvious association between specific restriction fragments and a genetic predisposition to malignancy. However, differences in the allele distribution in leukocyte and tumour DNAs of cancer p
## Abstract Our aim was to estimate the prevalence of mutations in the __BRCA1__ and __BRCA2__ genes among unselected incident cases of breast cancer in young women. We identified 158 incident breast cancer cases diagnosed before age 46 years in predefined geographic areas in Girona and Tarragona,
## Abstract Interleukin 1β (IL‐1β) is a multifunctional cytokine that upregulates the inflammatory response, and participates in carcinogenesis, malignant transformation, tumor growth, invasion and metastasis. Two potentially functional polymorphisms (T‐31C and C‐511T) in the __IL‐1__β gene promote
The cancer-associated epitope defined by the monoclonal antibody (MAb) 9H8 was shown to be closely related to the T antigen (Thornsen-Friedenreich antigen) by its sensitivity to 0-glycanase treatment of a mucin glycopeptide known to express this epitope. The reactivity with this glycopeptide increas