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Comparison between the allelic frequency distribution of the Ha-ras 1locus in normal individuals and patients with lymphoma, breast, and ovarian cancer

✍ Scribed by B. Corell; B. Zoll


Publisher
Springer
Year
1988
Tongue
English
Weight
432 KB
Volume
79
Category
Article
ISSN
0340-6717

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✦ Synopsis


Analysis of 426 alleles of the human Ha-rasl locus in DNA samples of cancer patients and controls reveals no obvious association between specific restriction fragments and a genetic predisposition to malignancy. However, differences in the allele distribution in leukocyte and tumour DNAs of cancer patients may be related to an involvement of the Ha-rasl gene in tumorigenesis.