Rapid synthesis of 2′,3′-dideoxycytidine (ddC) from a simple achiral precursor
✍ Scribed by Michael E. Jung; Claire Castro; John M. Gardiner
- Book ID
- 108382225
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 200 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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Ahstractz The acctyknii alcohol, 3, readily prepared in two steps from propargyl bromide. 1. is converted to ethyl 2dcoxy-D-xy1ofuTan0side. l3, and to the unnamml L-cnantiomer. 12, in 5 steps and 50% overall yield, utilizing asymmetrk dihydroxylation (AD) of alkcne 7 for intro&&m df chMity. A simila
A Novel Asymmetric Synthesis of 2-Azetidinones from Achiral Precursors. -Cyclocondensation of chloride (I) with p-methoxybenzylamine in the presence of stoichiometric amounts of a chiral salen-copper(II) is investigated. The desired azetidinone (III) is obtained with considerable enantioselectivity