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Rapid solid-Phase synthesis of DNA-Binding pyrrole-Imidazole polyamides

✍ Scribed by Peter O. Krutzik; A.Richard Chamberlin


Book ID
108477257
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
115 KB
Volume
12
Category
Article
ISSN
0960-894X

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Solid-phase synthesis of a folate tripyrrolocarboxamide conjugate 8 of a DNA binding polyamide is described. The synthesis of a new building block monomer Boc-Py-[(CH 2 ) 3 -NHFmoc] acid 3 is also reported.

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The development of the 2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl (Tsc) function, a novel base-sensitive amino-protecting group, and its application to the preparation of DNA-binding polyamides are described. Pyrrole-imidazole polyamides were synthesized by an efficient solid-phase method und