Rapid solid-Phase synthesis of DNA-Binding pyrrole-Imidazole polyamides
β Scribed by Peter O. Krutzik; A.Richard Chamberlin
- Book ID
- 108477257
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 115 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0960-894X
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π SIMILAR VOLUMES
The synthesis of the Nsc-protected amino acid, Nsc-Py-OH 1a, and its oligomerization are described.
Solid-phase synthesis of a folate tripyrrolocarboxamide conjugate 8 of a DNA binding polyamide is described. The synthesis of a new building block monomer Boc-Py-[(CH 2 ) 3 -NHFmoc] acid 3 is also reported.
The development of the 2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl (Tsc) function, a novel base-sensitive amino-protecting group, and its application to the preparation of DNA-binding polyamides are described. Pyrrole-imidazole polyamides were synthesized by an efficient solid-phase method und