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Synthesis and Biological Properties of Sequence-Specific DNA-Alkylating Pyrrole−Imidazole Polyamides

✍ Scribed by Bando, Toshikazu; Sugiyama, Hiroshi

Book ID
111916579
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
974 KB
Volume
39
Category
Article
ISSN
0001-4842

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✍ Shunta Sasaki; Toshikazu Bando; Masafumi Minoshima; Ken-ichi Shinohara; Hiroshi 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 676 KB

## Abstract To extend the target DNA sequence length of the hairpin pyrrole–imidazole (Py–Im) polyamide **1**, we designed and synthesized Y‐shaped and tandem hairpin Py–Im polyamides **2** and **3**, which possess 1‐(chloromethyl)‐5‐hydroxy‐1,2‐dihydro‐3__H__‐benz[__e__]indole (__seco__‐CBI) as DN