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Rapid solid-phase synthesis of bradykinin

✍ Scribed by Lila Corley; David H. Sachs; Christian B. Anfinsen


Book ID
118853026
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
306 KB
Volume
47
Category
Article
ISSN
0006-291X

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Rapid solid phase synthesis of Ξ±-amino a
✍ Mireille Barbaste; ValΓ©rie Rolland-Fulcrand; Marie-Louise Roumestant; Philippe V πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 201 KB

A solid phase synthetic method for amino acids is developed. The N-acetyl-dehydroalanine is quantitatively bound to Wang resin by the Mitsunobu method. Then a Michael addition is achieved on the double bond with different nucleophiles. Non proteinic N-acetyl-ct-amino acids are obtained after cleavag