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Rapid shift in genotype of human mitochondrial DNA in a family with Leber's hereditary optic neuropathy

✍ Scribed by P.A. Bolhuis; E.M. Bleeker-Wagemakers; N.J. Ponne; M.J. Van Schooneveld; A. Westerveld; C. Van den Bogert; H.F. Tabak


Book ID
115762745
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
304 KB
Volume
170
Category
Article
ISSN
0006-291X

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Mitochondrial DNA mutation in an Italian
✍ Carla Carducci; Vincenzo Leuzzi; Massimo Scuderi; Anna Maria Negri; Corrado Bala πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 305 KB

Mitochondrial (mt) DNA from a Southern Italian family with Leber hereditary optic neuropathy was analyzed for the presence of the reported mutation at position 11778 of the ND4 subunit gene. The point mutation was found in mt DNA extracted from peripheral blood in all members of the family with the