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MITOCHONDRIAL DNA MUTATION IN FAMILY WITH LEBER'S HEREDITARY OPTIC NEUROPATHY

✍ Scribed by Yoneda, Makoto; Tsuji, Shoji; Yamauchi, Toyoaki; Inuzuka, Takashi; Miyatake, Tadashi; Horai, Satoshi; Ozawa, Takayuki

Book ID
123175600
Publisher
The Lancet
Year
1989
Tongue
English
Weight
419 KB
Volume
333
Category
Article
ISSN
0140-6736

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Mitochondrial (mt) DNA from a Southern Italian family with Leber hereditary optic neuropathy was analyzed for the presence of the reported mutation at position 11778 of the ND4 subunit gene. The point mutation was found in mt DNA extracted from peripheral blood in all members of the family with the