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Only male matrilineal relatives with Leber’s hereditary optic neuropathy in a large Chinese family carrying the mitochondrial DNA G11778A mutation

✍ Scribed by Jia Qu; Ronghua Li; Yi Tong; Yongwu Hu; Xiangtian Zhou; Yaping Qian; Fan Lu; Min-Xin Guan


Book ID
116289930
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
294 KB
Volume
328
Category
Article
ISSN
0006-291X

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Leber's hereditary optic neuropathy (LHON) is characterized by acute or subacute bilateral (usually permanent) loss of central vision, caused by neuroretinal degeneration. The maternal inheritance is explained by the mitochondrial origin of the disease. Recently, a single mitochondrial DNA (mtDNA) m