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Brain stem lesion in mitochondrial DNA G11778A mutation of Leber's hereditary optic neuropathy

✍ Scribed by Chen, Yan-Ting; Chen, Wei-Liang; Chen, San-Ni; Liu, Chin-San


Book ID
122330014
Publisher
Chinese Electronic Periodical Services
Year
2015
Tongue
English
Weight
301 KB
Volume
114
Category
Article
ISSN
0929-6646

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Leber's hereditary optic neuropathy (LHON) is characterized by acute or subacute bilateral (usually permanent) loss of central vision, caused by neuroretinal degeneration. The maternal inheritance is explained by the mitochondrial origin of the disease. Recently, a single mitochondrial DNA (mtDNA) m

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Leber hereditary optic neuropathy (LHON) is a major cause of inherited blindness in young males. Approximately 1 in 7 individuals with LHON harbor a mixture of mutated and wild-type (normal) mtDNA (heteroplasmy), and the risks of developing blindness in heteroplasmic LHON individuals are not well ch