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Leber's hereditary optic neuropathy associated with a disorder indistinguishable from multiple sclerosis in a male harbouring the mitochondrial DNA 11778 mutation

✍ Scribed by N. K. Olsen; A. W. Hansen; S. Nørby; A. L. Edal; J. R. Jørgensen; T. Rosenberg


Book ID
114784531
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
511 KB
Volume
91
Category
Article
ISSN
0001-6314

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Leber's hereditary optic neuropathy (LHON) is characterized by acute or subacute bilateral (usually permanent) loss of central vision, caused by neuroretinal degeneration. The maternal inheritance is explained by the mitochondrial origin of the disease. Recently, a single mitochondrial DNA (mtDNA) m