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Rapid quantitation of flurazepam and its major metabolite, N-desalkylflurazepam, in human plasma by gas—liquid chromatography with electron-capture detection

✍ Scribed by Roberto Riva; Marco de Anna; Fiorenzo Albani; Agostino Baruzzi

Book ID
108449743
Publisher
Elsevier Science
Year
1981
Weight
306 KB
Volume
222
Category
Article
ISSN
0378-4347

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## Abstract A sensitive GC‐ECD assay has been developed for the simultaneous determination of midazolam (I) and its α‐hydroxy metabolite (II) in plasma. The assay involves extraction of both compounds into ether at alkaline pH (pH 12), followed by silylation of the α‐hydroxy metabolite with N,O‐bis