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Determination of isosorbide dinitrate and its two mononitrate metabolites in human plasma and saliva through gas-liquid chromatography with electron-capture detection

✍ Scribed by Syed Laik Ali; Henning Blume


Book ID
112325394
Publisher
Springer
Year
1985
Tongue
English
Weight
627 KB
Volume
321
Category
Article
ISSN
1618-2650

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## Abstract A sensitive GC‐ECD assay has been developed for the simultaneous determination of midazolam (I) and its α‐hydroxy metabolite (II) in plasma. The assay involves extraction of both compounds into ether at alkaline pH (pH 12), followed by silylation of the α‐hydroxy metabolite with N,O‐bis