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Rapid down-regulation of protein kinase C in (chediak-higashi syndrome) beige mouse by phorbol ester

✍ Scribed by Masahiko Ito; Fuminori Tanabe; Yoshiyuki Takami; Akihiko Sato; Shiro Shigeta


Book ID
117058576
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
484 KB
Volume
153
Category
Article
ISSN
0006-291X

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Induction of protein kinase C down-regul
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## Abstract Using a calpain/protein kinase C (PKC) complex, we were able to reproduce, __in vitro__, the induction of PKC down‐regulation by the phorbol ester 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA) which had been previously observed in cells. We show that TPA initiates this phenomenon by promo