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Possible role of Na+ influx in phorbol ester-induced down-regulation of protein kinase C in HL60 cells

✍ Scribed by Noriko Takeuchi; Eikichi Hashimoto; Toru Nakamura; Fumito Takeuchi; Kiyonao Sada; Hirohei Yamamura

Book ID: 115928043
Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 563 KB
Volume: 328
Category: Article
ISSN: 0014-5793
DOI: 10.1016/0014-5793(93)80944-p

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## Abstract Using a calpain/protein kinase C (PKC) complex, we were able to reproduce, __in vitro__, the induction of PKC down‐regulation by the phorbol ester 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA) which had been previously observed in cells. We show that TPA initiates this phenomenon by promo