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Rapid determination of benzalkonium chloride in pharmaceutical preparations with flow injection liquid—liquid extraction

✍ Scribed by J.J. Halvax; G. Wiese; J.A. Arp; J.M.P. Vermeer; W.P. Van Bennekom; A. Bult

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
927 KB
Volume
8
Category
Article
ISSN
0731-7085

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✦ Synopsis

Benzalkonium chloride was assayed by on-line extraction of the benzalkonium ion with picrate to chloroform. The absorbance of picrate was measured. The extractions were performed with a home-made flow injection extraction unit. Calibration curves (1.5-180 x 10(-4)% w/v) were straight lines (r = 0.9993) and the relative standard deviation of a series of injections was less than or equal to 2%. Pharmaceutical benzalkonium preparations, containing xylometazoline, timolol, phenylephrine or carbachol could also be assayed. The method was compared with a modified HPLC assay.

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