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Rapid 3D-T1 mapping of cartilage with variable flip angle and parallel imaging at 3.0T

✍ Scribed by Ligong Wang; Mark E. Schweitzer; Abraham Padua; Ravinder R. Regatte

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
359 KB
Volume
27
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To rapidly acquire T~1~‐weighted images using a three‐dimensional fast low angle shot (3D FLASH) sequence in combination with generalized autocalibrating partially parallel acquisitions (GRAPPA) and variable flip angle (VFA) method at 3.0T.

Materials and Methods

3D T~1~ maps of model systems (gadolinium [Gd] and agarose phantoms), bovine cartilage, and human subjects were constructed on a 3.0T clinical whole‐body MR scanner. The T~1~ values of model systems measured using the 2D inversion‐recovery fast‐spin‐echo (IR‐FSE) sequence were considered as a reference method to validate the rapid 3D method for comparison.

Results

The root mean square coefficient of variation percentage (RMS‐CV%) of the median T~1~ of agarose phantom across different acquisition methods was ∼6.2%. The RMS‐CV% of the median T~1~ of bovine cartilage across different acquisition methods was ∼4.1%. The RMS‐CV% of median T~1~ of the cartilages among the subjects was between ∼7.3% to 11.1%. In our study, rapid 3D‐T~1~ mapping with VFA and parallel imaging with different acceleration factors (AFs) (AF = 1, 2, 3, and 4) seems to have no obvious influence on the T~1~ mapping (before and after contrast agent administration).

Conclusion

The preliminary results demonstrate that it is possible to quantify 3D‐T~1~ mapping of the whole knee joint (with 0.7 mm^3^ isotropic resolution) under approximately five minutes with excellent in vivo reproducibility at 3.0T. J. Magn. Reson. Imaging 2007. © 2007 Wiley‐Liss, Inc.

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