## Abstract Menopause and increasing age are associated with a decrease in calcium absorption that can contribute to the pathogenesis of osteoporosis. We hypothesized that alendronate plus vitamin D~3~ (ALN + D) would increase fractional calcium absorption (FCA). In this randomized, double‐blind, p
✦ LIBER ✦
Randomized Trial of Alendronate Plus Vitamin D3Versus Standard Care in Osteoporotic Postmenopausal Women with Vitamin D Insufficiency
✍ Scribed by Stuart H. Ralston; Neil Binkley; Steven Boonen; Douglas P. Kiel; Jean-Yves Reginster; Christian Roux; Liang Chen; Elizabeth Rosenberg; Arthur Santora; Investigators of FOCUS-D (FOSAVANCE vs. Standard Care—Use and Study of Vitamin D) Trial
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 465 KB
- Volume
- 88
- Category
- Article
- ISSN
- 1432-0827
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## Abstract Most osteoporosis drugs act by inhibiting bone resorption. A need exists for osteoporosis therapies that stimulate new bone formation. 2‐Methylene‐19‐nor‐(20__S__)‐1α,25‐dihydroxyvitamin D~3~ (2MD) is a vitamin D analogue that potently stimulates bone formation activity in vitro and in