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Raltegravir does not revert efflux activity of MDR1-P-glycoprotein in human MDR cells

✍ Scribed by Maria Luisa Dupuis,Alessandro Ascione,Lucia Palmisano…

Book ID
121534742
Publisher
Springer (Biomed Central Ltd.)
Year
2013
Tongue
English
Weight
887 KB
Volume
14
Category
Article
ISSN
2050-6511

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The human multidrug resistance gene MDR1 encodes the protein product P-glycoprotein (P-gp). P-gp is an integral membrane protein which mediates ATP-dependent substrate efflux. We recently discovered a novel G --> T variant at 1199 nucleotide position of MDR1 which exhibits a 2.3% allelic frequency i