Expression of P-glycoprotein, encoded by MDR 1 gene, a metabolically active efflux pump in murine mast cells
β Scribed by David Wein; Sudhir Gupta
- Book ID
- 116123457
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 828 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0304-3835
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π SIMILAR VOLUMES
The human multidrug resistance gene MDR1 encodes the protein product P-glycoprotein (P-gp). P-gp is an integral membrane protein which mediates ATP-dependent substrate efflux. We recently discovered a novel G --> T variant at 1199 nucleotide position of MDR1 which exhibits a 2.3% allelic frequency i
Fatty acid ester surfactants Cremophor EL and Solutol H S I 5 were described earlier as modulators of multidrug resistance mediated by MDR I P-glycoprotein (Pgp). We have shown that the most active components of these polydisperse surfactants are fatty acid-polyethylene glycol-fatty acid diesters (F