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33 Expression of the MDR-1 gene-encoded P-glycoprotein (P-170) in chronically ischemic cardiomyocytes of sheep and pigs

✍ Scribed by Alberto J. Lazarowski; Hernán J. García Rivello; Rubén P. Laguens; Patricia M. Cabeza Meckert; Elena C. Lascano; Jorge A. Negroni; Héctor F. del Valle; Gustavo L. Vera Janavel; Alberto J. Crottogini


Book ID
117141702
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
147 KB
Volume
34
Category
Article
ISSN
0022-2828

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Expression of the MDR I (P-glycoprotein) gene confers resistance to several classes of chemotherapeutic drugs (multi-drug resistance). Colon carcinomas frequently express high levels of MDR I mRNA and P-glycoprotein, presumably reflecting the origin of these tumors from MDRl -expressing normal colon